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1
Kill all white people yo
2
Arts and Entertainment / Re: Twin Peaks Season 3
Last post by Testy Calibrate -
In lots of ways it probably has. If you haven't seen the original, yeah, you should.
3
Arts and Entertainment / Re: Twin Peaks Season 3
Last post by ksen -
Should I watch the original seasons first?

On the other hand, I feel that just reading testy's posts over the years has pretty much prepared me for the show.
4
So give us your best example of non-random evolution David.

No, not vague implications and assertions. An actual detailed example.
Antibiotic resistance in bacteria.  Where were you when we were discussing that?


How are the mutations which lead to antibiotic resistance non-random wrt function?
5
Oh. And this:
Here's another paper for Hawkins to ignore despite his professed interest in the roles of "RM" and "NS" in pathogen drug resistance:
Origins and Evolution of Antibiotic Resistance
Quote
The development of generations of antibiotic-resistant microbes and their distribution in microbial populations throughout the biosphere are the results of many years of unremitting selection pressure from human applications of antibiotics, via underuse, overuse, and misuse. This is not a natural process, but a man-made situation superimposed on nature; there is perhaps no better example of the Darwinian notions of selection and survival.
Quote
There have been no validated reports of a role for HGT in the development of resistance in M. tuberculosis. Antibiotic resistance in M. tuberculosis occurs exclusively by spontaneous mutation.
Quote
The genes for β-lactamase enzymes are probably the most international in distribution; random mutations of the genes encoding the enzymes have given rise to modified catalysts with increasingly extended spectra of resistance (63).
Quote
The CTX-M genes and subsequent variants (upwards of 100 different amino acid substitutions have been identified so far) are highly successful at transmission and are a global phenomenon and threat (Fig. ​(Fig.3)3) (71). Such epidemics of r genes with efficient HGT and rapid mutational radiation are next to impossible to control.
6
So give us your best example of non-random evolution David.

No, not vague implications and assertions. An actual detailed example.
Antibiotic resistance in bacteria.  Where were you when we were discussing that?

Here's an actual detailed example.
Perhaps you missed it earlier.
Here's yet another article on which Hawkins will :lalala:

Evolution of extended-spectrum β-lactamases by mutation

From the abstract:
Quote
Many ESBLs [extended-spectrum beta-lactamases] are generated by mutations in genes coding for broad-spectrum enzymes, which have been mobile since at least the 1960s and which have disseminated very widely in populations of pathogenic bacteria. Strong selection pressure exerted by antimicrobial use, especially with newer generation β-lactam antibiotics, efficiently promotes these two modes [i.e. "RM" and "NS" - VR] of ESBL emergence and subsequent spread. It also stimulates further evolution of ESBLs by accumulation of other mutations with an astonishing variety of effects on β-lactamase structure and activity.

This is really important, as ESBL's constitute perhaps THE most notorious class of  "superbug" resistance mechanisms.
7
Dude changed the rules. Shoot first, ask questions later.
8
Science / Re: Direct Down Wind Faster Than The Wind
Last post by arpie -
If humber was just trolling..quite possible..then I was his biggest success wrt time wasted in emails trying to get him to answer some key questions. I really had hoped he'd see it in time. But the fact he just dropped out without any apologies or further rebuttals I found quite disappointing.

But here's the problem. There is no doubt in my dissembling mind that humber, Harold, and Heinz are all far more intelligent than I am. They know more about the physics involved in this epic thread. So it long troubled me that there wasn't a total consensus on what to me had appeared as a no-brainer. A sailboat can't use leverage as BB did. I couldn't begin to lift my truck, but with a jack I can.

That humber was a master at presenting multiple arguments minutes apart, to me is obvious. And tbh it was part of my doubt. That such a bright, informed group of people that I witnessed making long rebuttals to his claims, made me wonder why they would bother.  Going back to JREF in '07 and onto RDF. When humber was banned there, the thread died. When spork started it here, after a few months of Harold getting involved it was again dying until humber returned. Then it soared to 110 pages from the thirties before he came back, in just 6 days. It ended with over 5k pages just here.

@ridgerunner -Still hoping you will do those long promised videos of your latest cart exceeding wind speed. Yours is the most advanced TM testable cart I'm aware of, and I still have some doubt if the much smaller blade and loss of traction won't make any difference. This is especially true given how long it took the many universities participating in the Aeolus runs to just achieve wind speed. The differential in prop size between those carts and BB is far less than that of any TM capable cart I'm guessing, but would love to see proof I'm wrong.
9
That was exactly what i was referring to
10
Can non random mutation cause speciation?