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Messages - Atheistoclast

1
Clastieeeeeeee!

Been busy writing a paper on EUKARYOGENESIS..
Care to give us an excerpt? 

Clue: it is about the origins of  HISTONES.
Can't you give us the abstract or something?  You're not doing alignments and counting differences again, are you?

Yes. It is about amino acid alignments and the differences between them. So is the paper on NOTCH.
2
Clastieeeeeeee!

Been busy writing a paper on EUKARYOGENESIS..
Care to give us an excerpt?  

Clue: it is about the origins of  HISTONES.
3
Clastieeeeeeee!

Been busy writing a paper on EUKARYOGENESIS..
4
Well one interesting thing is that the original gene got duplicated, and so was free to mutate, especially as it was only partly duplicated in the first place and so the original duplicate was non-functional anyway.  But because of its similarity to the original, it was able to be mutated back into functionality by being "overwritten" at some stage by the original.

Which is a nice counter-illustration to the idea that once a sequence has become "junk" it can't be unjunked again by "chance". Clearly there are mechanisms by which a later mutation can actually restore some of the original sequence.

At least that's my read of the article.  Perhaps a genetics person can weigh in.


That shows your complete miscomprehension of this paper and the field of genetics in general.
5
Nice article about a fascinating story

Another just-so story. More of the same evo-devo mumbo jumbo. The full article can be read here:  https://www.cell.com/cell/fulltext/S0092-8674(18)30383-0

I am not convinced that the NOTCH2NL add-on really is missing in the great apes. The authors did a very brief search:

Quote
Unlike human, both chimpanzee and gorilla have variable read depth over the region encompassing their NOTCH2NL-like sequences. This pattern suggests the existence of multiple versions of truncated NOTCH2NL-like genes in these species (Figure 2A). Consistent with this, we identified several different transcribed NOTCH2NL-like genes in chimpanzee. However, sequencing revealed that none of these genes encode NOTCH2-related proteins (Figures 2B and S2).

I would recommended rejection if I were the assigned reviewer.
6
Nice article about a fascinating story

Another just-so story. More of the same evo-devo mumbo jumbo. The full article can be read here:  https://www.cell.com/cell/fulltext/S0092-8674(18)30383-0

I am not convinced that the NOTCH2NL add-on really is missing in the great apes. The authors did a very brief search:

Quote
Unlike human, both chimpanzee and gorilla have variable read depth over the region encompassing their NOTCH2NL-like sequences. This pattern suggests the existence of multiple versions of truncated NOTCH2NL-like genes in these species (Figure 2A). Consistent with this, we identified several different transcribed NOTCH2NL-like genes in chimpanzee. However, sequencing revealed that none of these genes encode NOTCH2-related proteins (Figures 2B and S2).
7
Politics and Current Events / Re: Removing Assad

You fucking Americans! You hit a centre producing antitodes  for snake and scorpion poison: https://www.hindustantimes.com/world-news/at-destroyed-syria-lab-workers-say-they-produce-antidotes-to-snake-venom-not-toxic-weapons/story-e2OIzVf2RqPMMuRK0XdK0H.html

The OPCW inspected the Barzeh research facility last November and found nothing suspicious: https://pbs.twimg.com/media/DawDT9DW4AAjNNO.jpg

Of course dumbass CIA experts can't tell the difference between sarin and a neurotoxin produced by a scorpion. As a biologist, I know!
8
Politics and Current Events / Re: Removing Assad
Clastieeeeeeeeee!

Howdie! I was going to retaliate for these strikes, but they turned out to be a fireworks display.
9
Politics and Current Events / Re: Removing Assad
Trump declares 'mission accomplished' in Syria strike





Rattie, scientific research facilities were hit last night. You should be outraged on behalf of all scientists like yourself.
10
Politics and Current Events / Re: Removing Assad
lol Persians
According to Trump, I and others like me, are "great negotiators":  https://www.youtube.com/watch?v=HAre0tciWe0

He failed to mention that we are "great scientists" too!
11
Politics and Current Events / Re: Removing Assad
You do realize that all you Americanos will become targets for retaliation by Iranians like me?

Listen dahati...
the only threat you impose is that I would have to scrape off  & sanitize the bottom of my boot after stomping you.


OOOHH...I'm scared... You know one Persian word! I am proud of my peasant/rural roots. It's why I am a biologist.

Meanwhile, 2,000 Americanos in eastern Syria are nicely lined up for target practice.
12
Politics and Current Events / Re: Removing Assad
finally, trump can answer all his critics claiming he's a russian stooge by starting another fucking war.

You do realize that all you Americanos will become targets for retaliation by Iranians like me?
13
Politics and Current Events / Re: Removing Assad
You guess he is running things?  Something "should happen"?  Way to take the leadership role there, triple-chins!

We are heading for a friggin THIRD WORLD WAR
14
Links or it didn't happen Clastie.

I provided the link to the celebration above.
15
I am unable to travel to Manchester in February.
Can I purchase your book on Amazon?

Yes. Not "Gorillas in the Mist", "Atheist in the Mist".

Ok.
Would you give me a preview of your book?
Something to stimulate my interest ...

Quote the one sentence (that you wrote in the book) that you are most proud of.

It's ok if the one stand-alone sentence seems disjointed.

From page 74:

"Atheists have this smarter-than-thou attitude that really annoys believers. But for all of this..........END OF PREVIEW"
16
inB4 "it's missing"

Good things come to those who wait. Evolution is a gradual process.
17
I am unable to travel to Manchester in February.
Can I purchase your book on Amazon?

Yes. Not "Gorillas in the Mist", "Atheist in the Mist".

I couldn't find it on Amazon. Do you have a link?
There will also be a dinner with yours truly with tickets starting at £20.
What's the menu?

Starter: Primordial soup with croutons.
Main course:  Fillet of Tiktaalik sauteed in onions.
Dessert:  Lucy mud pie.
18
I am unable to travel to Manchester in February.
Can I purchase your book on Amazon?

Yes. Not "Gorillas in the Mist", "Atheist in the Mist".
19
Alternative Reality Science Extravaganza / Darwin Day!

Christmas is over, but Darwimas is right around the corner!  :clap:

If you just happen to be in Manchester UK, there is an event on to celebrate the great day: "HUMAN EVOLUTION: from Australopithecus to Archaeological Science" https://www.eventbrite.co.uk/e/darwin-day-celebration-2018-tickets-41679270821

After the event, I will doing a book signing for my latest publication, "Atheists in the Mist: the death throes of non-belief". There will also be a dinner with yours truly with tickets starting at £20.  So, what are you waiting for?
20
Science / Re: Piggies really are quasi-primates
Anyway, its 2017, Joe.  You don't need to propose nonsense like polyphyly as a rationalization for why you find farm animals so goddamned sexy.  Let your freak flag fly!

I see no reason why pigs could be a special case...a hybid between cows and monkeys.


21
Science / Re: Piggies really are quasi-primates


The evolutionists insist on monophyly.  The data suggest polyphyly.
22
Science / Piggies really are quasi-primates

A few years back, I claimed that my own research showed that pigs were unlike their artiodactylan cousins and more like primates. I was riducled on this very site for making such a bold claim.  I am pleased to my scientific peers have confirmed my findings.

https://phys.org/news/2015-09-hidden-evolutionary-relationship-pigs-primates.html
http://www.biorxiv.org/content/biorxiv/early/2015/08/31/025791.full.pdf

Quote
We  identified  and  characterized  a  free  PRE-1  element  inserted  into  the  promoter  region  of  the 
porcine  IGFBP7 gene  whose  integration  mechanisms  into  the  genome,  including  copy  number, 
distribution  preferences,  capacity  to  exonize  and  phyloclustering  pattern  are  similar  to  that  of  the 
primate  Alu  element.  98%  of  these  PRE-1  elements  also  contain  two  conserved  internal  AluI 
restriction enzyme recognition sites, and the RNA structure of PRE1 can be folded into a two arms
model like the Alu RNA structure. It is more surprising that the length of the PRE-1 fragments is
nearly  the  same  in  20  chromosomes  and  positively  correlated  to  its  fracture  site  frequency.  All  of 
these  fracture  sites  are  close  to  the  mutation  hot  spots  of  PRE-1  families,  and  most  of  these 
hot  spots  are  located  in  the  non-complementary  fragile  regions  of  the  PRE-1  RNA  structure. 
Sequence   homology   analysis   showed   that   the   PRE-1   element   seemed   to   share   a   common  
ancestor  7SL  RNA  with  primates  but  was  generated  by  different  evolutionary  model,  which 
suggests that the suidae may be the closest relatives to primates in laurasiatheria.

https://www.mnn.com/earth-matters/animals/stories/pigs-and-humans-more-closely-related-thought-according-genetic-analysis
The upshot of all of this, according to the study's author, is that the suidae family (that is, the swine family) could conceivably be grouped into a family that is otherwise mostly inhabited by primates, at least in terms of 7SL RNA-derived SINEs.
23
Science / Re: Clastie e-letter published
Wow, you effectively managed to post a "comment" on a website. ROFL.

Not everyone gets to publish these e-letters. They are screened by the powers that be.
25

I gave up on the DI and ID long ago. At first, I...
Aaaaand stopped reading.

I am now very much into niche construction.